SIP1 Antikörper (C-Term)

Produktnummer ABIN1887284

Produktdetails anti-SIP1 Antikörper

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human SIP1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu SIP1

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Andere Bezeichnung: SIP1 (GEMIN2 Produkte)

Synonyme: SIP1 antikoerper, SIP1-delta antikoerper, 1700012N19Rik antikoerper, Sip1 antikoerper, sip1 antikoerper, sip1-delta antikoerper, wu:fc52a05 antikoerper, zgc:110274 antikoerper, gem nuclear organelle associated protein 2 antikoerper, gem (nuclear organelle) associated protein 2 antikoerper, gem nuclear organelle associated protein 2 S homeolog antikoerper, GEMIN2 antikoerper, Gemin2 antikoerper, gemin2.S antikoerper, gemin2 antikoerper

Hintergrund: SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins.The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing.SIP1 interacts directly with the SMN and it is required for formation of the SMN complex.A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
Synonyms: Survival of motor neuron protein-interacting protein 1, GEMIN2

Pathways: Ribonucleoprotein Complex Subunit Organization, Tube Formation