EI24 Antikörper (C-Term)

Produktnummer ABIN1887276

Produktdetails anti-EI24 Antikörper

Target: EI24 (Etoposide Induced 2.4 (EI24))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EI24 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: At least two isoforms of EI24 are known to exist, this antibody will only detect the larger isoform.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human EI24.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu EI24

Target: EI24 (Etoposide Induced 2.4 (EI24))

Andere Bezeichnung: EI24 (EI24 Produkte)

Synonyme: EPG4 antikoerper, PIG8 antikoerper, TP53I8 antikoerper, AA536736 antikoerper, AI115355 antikoerper, EI24, autophagy associated transmembrane protein antikoerper, etoposide induced 2.4 mRNA antikoerper, EI24 antikoerper, Ei24 antikoerper

Hintergrund: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor.EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER).It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2.EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness.Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.
Synonyms: Etoposide-induced 24, PIG8, EPG4, TP53I8

NCBI Accession: NP_004870