LRRTM3 Antikörper (C-Term)

Produktnummer ABIN1887246

Produktdetails anti-LRRTM3 Antikörper

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Bindungsspezifität: C-Term

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRTM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human LRRTM3.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu LRRTM3

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Andere Bezeichnung: LRRTM3 (LRRTM3 Produkte)

Synonyme: 9630044H04Rik antikoerper, leucine rich repeat transmembrane neuronal 3 antikoerper, LRRTM3 antikoerper, lrrtm3 antikoerper, Lrrtm3 antikoerper

Hintergrund: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation.Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques.Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.
Synonyms: Leucine-rich repeat transmembrane neuronal protein 3

NCBI Accession: NP_821079

Pathways: Synaptic Membrane