STEAP1 Antikörper (C-Term)

Produktnummer ABIN1887239

Produktdetails anti-STEAP1 Antikörper

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STEAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität (Details): This STEAP1 antibody does not cross-react with other STEAP proteins.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the carboxy terminus of human STEAP1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu STEAP1

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Andere Bezeichnung: STEAP1 (STEAP1 Produkte)

Synonyme: PRSS24 antikoerper, STEAP antikoerper, STEAP1 antikoerper, 2410007B19Rik antikoerper, Prss24 antikoerper, Steap antikoerper, STEAP family member 1 antikoerper, six transmembrane epithelial antigen of the prostate 1 antikoerper, STEAP1 antikoerper, Steap1 antikoerper

Hintergrund: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue.The normal function of STEAP is still uncertain, unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity.However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers.Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy.At least three isoforms of STEAP1 are known to exist.
Synonyms: Six transmembrane epithelial antigen of prostate 1, STEAP

Pathways: Transition Metal Ion Homeostasis