TMEM38B Antikörper (C-Term)

Produktnummer ABIN1887180

Produktdetails anti-TMEM38B Antikörper

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM38B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide from near the carboxy terminus of human TMEM38B.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu TMEM38B

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Andere Bezeichnung: TMEM38B (TMEM38B Produkte)

Synonyme: zgc:55815 antikoerper, tricb antikoerper, tric-b antikoerper, MGC83592 antikoerper, DKFZp469C0220 antikoerper, C9orf87 antikoerper, D4Ertd89e antikoerper, OI14 antikoerper, TRIC-B antikoerper, TRICB antikoerper, bA219P18.1 antikoerper, 1600017F22Rik antikoerper, AA437809 antikoerper, AV051057 antikoerper, mg33b antikoerper, RGD1305703 antikoerper, transmembrane protein 38B antikoerper, transmembrane protein 38B L homeolog antikoerper, tmem38b antikoerper, TMEM38B antikoerper, tmem38b.L antikoerper, Tmem38b antikoerper

Hintergrund: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes.TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain.Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores.Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation.Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Synonyms: Transmembrane protein 38B, TRIC-B, TRICB, trimeric cation channel type B

NCBI Accession: NP_060582