S1PR1 Antikörper (C-Term)

Produktnummer ABIN1886995

Produktdetails anti-S1PR1 Antikörper

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: At least two isoforms of S1P1 are known to exist, this S1P1 antibody will only recognize the shorter isoform.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the carboxy terminus of the human S1P1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu S1PR1

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Andere Bezeichnung: S1P1 (S1PR1 Produkte)

Synonyme: CD363 antikoerper, CHEDG1 antikoerper, D1S3362 antikoerper, ECGF1 antikoerper, EDG-1 antikoerper, EDG1 antikoerper, S1P1 antikoerper, AI849002 antikoerper, Edg1 antikoerper, Lpb1 antikoerper, S1p antikoerper, S1p1 antikoerper, S1P receptor 1 antikoerper, S1P receptor Edg-1 antikoerper, edg1 antikoerper, etID43307.22 antikoerper, s1p1 antikoerper, wu:fb98f05 antikoerper, s1pr1 antikoerper, xts1p1 antikoerper, sphingosine-1-phosphate receptor 1 antikoerper, sphingosine-1-phosphate receptor 1 L homeolog antikoerper, S1PR1 antikoerper, S1pr1 antikoerper, s1pr1 antikoerper, s1pr1.L antikoerper

Hintergrund: Movement of lymphocytes through lymphoid organs is required for generating immunity.Their migration into lymph nodes follows a series of events including integrin activation through chemokine signaling, adhesion and diapedis.The release of lymphocytes from lymph nodes is regulated by the phospholipid sphingosine-1-phosphate (S1P).One of its receptors S1P1 binds S1P with highand affinity, agonism of this receptor by the immunosuppressive agent FTY720 inhibits the entry of tissue T cells into afferent lymphatics in homeostatic and inflammatory conditions.Recent experiments have indicated that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did and these cells where also less effectively retained after treatment with FTY720, and that egress competence could be restored by inactivating G alpha i-protein-coupled receptor signaling.These results suggest that S1P1 acts in the lymphocyte to promote lymph node egress by overcoming retention signals mediated by CCR7 and G alpha i-protein-coupled receptor signaling.
Synonyms: Sphingosine-1-phosphate receptor 1, S1PR1, EDG1, ECGF1

NCBI Accession: NP_001391

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2