OTUD5 Antikörper (C-Term)

Produktnummer ABIN1886937

Produktdetails anti-OTUD5 Antikörper

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTUD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide near the carboxy terminus of the human OTUD5.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu OTUD5

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Andere Bezeichnung: OTUD5 (OTUD5 Produkte)

Synonyme: DUBA antikoerper, AA407879 antikoerper, AI553596 antikoerper, BB114028 antikoerper, DXImx46e antikoerper, Sfc7 antikoerper, otud5 antikoerper, si:bz30i22.1 antikoerper, si:rp71-30i22.1 antikoerper, zgc:154072 antikoerper, wu:fi28a06 antikoerper, zgc:100839 antikoerper, OTU deubiquitinase 5 antikoerper, OTU domain containing 5 antikoerper, OTU deubiquitinase 5a antikoerper, OTU deubiquitinase 5 S homeolog antikoerper, OTU deubiquitinase 5 L homeolog antikoerper, OTU deubiquitinase 5b antikoerper, OTUD5 antikoerper, Otud5 antikoerper, otud5a antikoerper, otud5.S antikoerper, otud5.L antikoerper, otud5b antikoerper

Hintergrund: OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily.The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein.Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses.It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus.Multiple isoforms of OTUD5 are known to exist.
Synonyms: OTU domain-containing protein 5, Deubiquitinating enzyme A, DUBA