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GSG2 Antikörper (AA 323-352)

GSG2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB3404 unconjugated
Produktnummer ABIN1882168
  • Target Alle GSG2 Antikörper anzeigen
    GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))
    Bindungsspezifität
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 323-352
    Reaktivität
    • 23
    • 3
    • 3
    • 2
    • 1
    Human
    Wirt
    • 25
    • 2
    Kaninchen
    Klonalität
    • 26
    • 1
    Polyklonal
    Konjugat
    • 13
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GSG2 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 8
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Haspin GSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323~352 amino acids from the central region of human haspin.
    Klon
    RB3404
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Dai, Sultan, Taylor, Higgins: "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment." in: Genes & development, Vol. 19, Issue 4, pp. 472-88, (2005) (PubMed).

    Higgins: "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells." in: Gene, Vol. 267, Issue 1, pp. 55-69, (2001) (PubMed).

    Tanaka, Iguchi, Nakamura, Kohroki, de Carvalho, Nishimune: "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase." in: Molecular human reproduction, Vol. 7, Issue 3, pp. 211-8, (2001) (PubMed).

  • Target
    GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))
    Andere Bezeichnung
    Haspin GSG2 (GSG2 Produkte)
    Synonyme
    BcDNA:LD07633 antikoerper, CG40080 antikoerper, Dmel\\CG40080 antikoerper, haspin antikoerper, NV16901 antikoerper, HASPIN antikoerper, Haspin antikoerper, putative serine/threonine-protein kinase haspin homolog antikoerper, histone H3 associated protein kinase antikoerper, CG40080 gene product from transcript CG40080-RA antikoerper, uncharacterized LOC100122327 antikoerper, LOC552287 antikoerper, HASPIN antikoerper, Haspin antikoerper, LOC100122327 antikoerper
    Hintergrund
    Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Mitotic phosphorylation of H3 Thr 3 occurs in prophase and dephosphorylation during anaphase. Haspin, a dual serine/threonine kinase, plays an important role in regulation of chromosome and spindle function during mitosis and meiosis via its function in phosphorylation of the threonine residue in the third position of histone 3 (Thr3).
    Molekulargewicht
    88495
    NCBI Accession
    NP_114171
    UniProt
    Q8TF76
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