IKBKB
Reaktivität: Human
ELISA, WB, IHC, IF
Wirt: Kaninchen
Monoclonal
3E1
unconjugated
Recombinant Antibody
Applikationshinweise
WB: 1:100~500
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Tarantino, Tinevez, Crowell, Boisson, Henriques, Mhlanga, Agou, Israël, Laplantine: "TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures." in: The Journal of cell biology, Vol. 204, Issue 2, pp. 231-45, (2014) (PubMed).
Sun, Wang, Zhao, Yu, Fan, Wang, Wang, Lu, Zhang, Fu, Yang: "Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21341-8, (2010) (PubMed).
Potter, Cordell, Barton, Daly, Hyrich, Mann, Morgan, Wilson, Isaacs: "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1315-20, (2010) (PubMed).
Niida, Tanaka, Kamitani: "Downregulation of active IKK beta by Ro52-mediated autophagy." in: Molecular immunology, Vol. 47, Issue 14, pp. 2378-87, (2010) (PubMed).
Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, (2010) (PubMed).
Lobry, Lopez, Israël, Weil: "Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 3, pp. 908-13, (2007) (PubMed).
Edwards: "Anticipation of disaster." in: Journal of the Royal Society of Medicine, Vol. 84, Issue 5, pp. 323, (1991) (PubMed).
Target
IKBKB
(Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).