USH1C Antikörper (N-Term)

Produktnummer ABIN1881984

Produktdetails anti-USH1C Antikörper

Target: USH1C (Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USH1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This USH1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USH1C.

Klon: RB41722

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-USH1C Antikörper (ABIN1881984)

Yan, Pan, Chen, Wu, Zhang: "The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 9, pp. 4040-5, (2010) (PubMed).

Jaijo, Aller, García-García, Aparisi, Bernal, Avila-Fernández, Barragán, Baiget, Ayuso, Antiñolo, Díaz-Llopis, Külm, Beneyto, Nájera, Millán: "Microarray-based mutation analysis of 183 Spanish families with Usher syndrome." in: Investigative ophthalmology & visual science, Vol. 51, Issue 3, pp. 1311-7, (2010) (PubMed).

Pan, Yan, Wu, Zhang: "Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 14, pp. 5575-80, (2009) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Details zu USH1C

Target: USH1C (Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C))

Andere Bezeichnung: USH1C (USH1C Produkte)

Synonyme: AIE-75 antikoerper, DFNB18 antikoerper, DFNB18A antikoerper, NY-CO-37 antikoerper, NY-CO-38 antikoerper, PDZ-45 antikoerper, PDZ-73 antikoerper, PDZ-73/NY-CO-38 antikoerper, PDZ73 antikoerper, PDZD7C antikoerper, ush1cpst antikoerper, 2010016F01Rik antikoerper, harmonin antikoerper, zgc:136806 antikoerper, ush1c antikoerper, USH1 protein network component harmonin antikoerper, harmonin antikoerper, Usher syndrome 1C antikoerper, USH1 protein network component harmonin L homeolog antikoerper, USH1C antikoerper, CpipJ_CPIJ012732 antikoerper, Ush1c antikoerper, ush1c antikoerper, ush1c.L antikoerper

Hintergrund: This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 62211

NCBI Accession: NP_005700, NP_710142

UniProt: Q9Y6N9

Pathways: Sensory Perception of Sound