PIGB Antikörper (N-Term)

Produktnummer ABIN1881653

Produktdetails anti-PIGB Antikörper

Target: PIGB (Phosphatidylinositol Glycan Anchor Biosynthesis, Class B (PIGB))

Bindungsspezifität: AA 28-56, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIGB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PIGB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human PIGB.

Klon: RB32518

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PIGB Antikörper (ABIN1881653)

Hwang, Hayashi, Kita, Takahashi, Kuge, Naganuma: "siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells." in: The Journal of toxicological sciences, Vol. 32, Issue 5, pp. 581-3, (2008) (PubMed).

Anikster, Huizing, Anderson, Fitzpatrick, Klar, Gross-Kieselstein, Berkun, Shazberg, Gahl, Hurvitz: "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A." in: American journal of human genetics, Vol. 71, Issue 2, pp. 407-14, (2002) (PubMed).

Kinoshita, Inoue: "Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis." in: Current opinion in chemical biology, Vol. 4, Issue 6, pp. 632-8, (2001) (PubMed).

Takahashi, Inoue, Ohishi, Maeda, Nakamura, Endo, Fujita, Takeda, Kinoshita: "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor." in: The EMBO journal, Vol. 15, Issue 16, pp. 4254-61, (1996) (PubMed).

Details zu PIGB

Target: PIGB (Phosphatidylinositol Glycan Anchor Biosynthesis, Class B (PIGB))

Andere Bezeichnung: PIGB (PIGB Produkte)

Synonyme: GPI-MT-III antikoerper, PIG-B antikoerper, Pig-b antikoerper, phosphatidylinositol glycan anchor biosynthesis, class B antikoerper, phosphatidylinositol glycan anchor biosynthesis class B antikoerper, phosphatidylinositol glycan anchor biosynthesis class B S homeolog antikoerper, Pigb antikoerper, PIGB antikoerper, pigb.S antikoerper

Hintergrund: This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.

Molekulargewicht: 65056

NCBI Accession: NP_004846

UniProt: Q92521

Pathways: Inositol Metabolic Process