This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This KCNMB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNMB2.
Lee, Cui: "{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia." in: The Journal of physiology, Vol. 587, Issue Pt 7, pp. 1481-98, (2009) (PubMed).
Zarei, Song, Wilson, Cox, Colom, Knaus, Stefani, Toro: "Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel." in: Neuroscience, Vol. 147, Issue 1, pp. 80-9, (2007) (PubMed).
Zeng, Benzinger, Xia, Lingle: "BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 17, pp. 4707-15, (2007) (PubMed).
Orio, Torres, Rojas, Carvacho, Garcia, Toro, Valverde, Latorre: "Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel." in: The Journal of general physiology, Vol. 127, Issue 2, pp. 191-204, (2006) (PubMed).
Target
KCNMB2
(Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))
KCNMB3 antikoerper, zgc:101842 antikoerper, KCNMB2 antikoerper, 2700049B16Rik antikoerper, 3110031N04Rik antikoerper, Kcmb2 antikoerper, potassium calcium-activated channel subfamily M regulatory beta subunit 2 antikoerper, potassium large conductance calcium-activated channel, subfamily M, beta member 2 antikoerper, KCNMB2 antikoerper, kcnmb2 antikoerper, Kcnmb2 antikoerper
Hintergrund
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene. [provided by RefSeq].