HLA-DQA2 Antikörper (AA 39-66)

Produktnummer ABIN1881421

Produktdetails anti-HLA-DQA2 Antikörper

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Bindungsspezifität: AA 39-66

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DQA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HLA-DQA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human HLA-DQA2.

Klon: RB42054

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-HLA-DQA2 Antikörper (ABIN1881421)

Hor, Kutalik, Dauvilliers, Valsesia, Lammers, Donjacour, Iranzo, Santamaria, Peraita Adrados, Vicario, Overeem, Arnulf, Theodorou, Jennum, Knudsen, Bassetti: "Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy." in: Nature genetics, Vol. 42, Issue 9, pp. 786-9, (2010) (PubMed).

Petukhova, Duvic, Hordinsky, Norris, Price, Shimomura, Kim, Singh, Lee, Chen, Meyer, Paus, Jahoda, Amos, Gregersen, Christiano: "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity." in: Nature, Vol. 466, Issue 7302, pp. 113-7, (2010) (PubMed).

Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Details zu HLA-DQA2

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Andere Bezeichnung: HLA-DQA2 (HLA-DQA2 Produkte)

Synonyme: DX-ALPHA antikoerper, HLA-DXA antikoerper, major histocompatibility complex, class II, DQ alpha 2 antikoerper, HLA-DQA2 antikoerper

Hintergrund: This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq].

Molekulargewicht: 28033

NCBI Accession: NP_064440

UniProt: P01906

Pathways: T-Zell Rezeptor Signalweg