HIST2H2BE Antikörper (N-Term)

Produktnummer ABIN1881418

Produktdetails anti-HIST2H2BE Antikörper

Target: HIST2H2BE (Histone H2B Type 2-E (HIST2H2BE))

Bindungsspezifität: AA 12-40, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIST2H2BE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HIST2H2BE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human HIST2H2BE.

Klon: RB41930

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-HIST2H2BE Antikörper (ABIN1881418)

Kim, Guermah, McGinty, Lee, Tang, Milne, Shilatifard, Muir, Roeder: "RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells." in: Cell, Vol. 137, Issue 3, pp. 459-71, (2009) (PubMed).

Pankratova, Manuĭlova, Stepchenko: "[Role of transcription factors binding sites in no-mediated histone H2B promoter repression]." in: Molekuliarnaia biologiia, Vol. 43, Issue 2, pp. 368-73, (2009) (PubMed).

Dai, Yu, Goh, Chng, Tan, Fu, Zheng, Luo: "Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status." in: The Journal of biological chemistry, Vol. 283, Issue 40, pp. 26894-901, (2008) (PubMed).

Zhao, Lang, Ito, Bonnet, Metzger, Sawatsubashi, Suzuki, Le Guezennec, Stunnenberg, Krasnov, Georgieva, Schüle, Takeyama, Kato, Tora, Devys: "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing." in: Molecular cell, Vol. 29, Issue 1, pp. 92-101, (2008) (PubMed).

Kawasaki, Schiltz, Chiu, Itakura, Taira, Nakatani, Yokoyama: "ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation." in: Nature, Vol. 405, Issue 6783, pp. 195-200, (2000) (PubMed).

Details zu HIST2H2BE

Target: HIST2H2BE (Histone H2B Type 2-E (HIST2H2BE))

Andere Bezeichnung: HIST2H2BE (HIST2H2BE Produkte)

Synonyme: RGD1562346 antikoerper, AV127319 antikoerper, H2b-613 antikoerper, T25626 antikoerper, DKFZp469C0528 antikoerper, H2b antikoerper, GL105 antikoerper, H2B antikoerper, H2B.1 antikoerper, H2BFQ antikoerper, H2BGL105 antikoerper, H2BQ antikoerper, histone cluster 2 H2B family member E antikoerper, histone cluster 2, H2be antikoerper, histone cluster 1, H2bl antikoerper, histone cluster 2 H2B family member e antikoerper, histone H2B antikoerper, Hist2h2be antikoerper, HIST2H2BE antikoerper, Hist1h2bl antikoerper, H2B antikoerper

Hintergrund: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Molekulargewicht: 13920

NCBI Accession: NP_003519

UniProt: Q16778