Desmoglein 1 Antikörper

Produktnummer ABIN187347

Produktdetails anti-Desmoglein 1 Antikörper

Target: Desmoglein 1 (DSG1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmoglein 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: The antibody reacts with the 165 kDa desmoglein 1 protein. Furthermore it does NOT cross-react with desmoglein 2 or desmolglein 3. Clone 27B2 does NOT inhibit the biological activity of desmolein 1. Species Reactivity: Human. Others not tested.

Sterilität: 0.2 μm filtered

Klon: 27B2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunofluorescence: Use at a 1:10 dilution. Immunohistology: frozen sections Immunoprecipitation: Use at a 1:10 dilution. Western blotting The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% protein stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu Desmoglein 1

Target: Desmoglein 1 (DSG1)

Andere Bezeichnung: Desmoglein-1 (DSG1 Produkte)

Synonyme: CDHF4 antikoerper, DG1 antikoerper, DSG antikoerper, PPKS1 antikoerper, SPPK1 antikoerper, DSG-1 antikoerper, DSG1 antikoerper, Dsg1b antikoerper, Dsg1c antikoerper, desmoglein 1 antikoerper, desmoglein 4 antikoerper, DSG1 antikoerper, DSG4 antikoerper, Dsg1 antikoerper

Hintergrund: Desmoglein 1 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmolgein 1 is essential to epidermal integrity.

Pathways: Cell-Cell Junction Organization