NR1I2 Antikörper (AA 205-390)

Produktnummer ABIN1860380

Produktdetails anti-NR1I2 Antikörper

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Bindungsspezifität: AA 205-390

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1I2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Verwendungszweck: Polyclonal Antibody to Pregnane X Receptor (PXR)

Spezifität: The antibody is a rabbit polyclonal antibody raised against PXR. It has been selected for its ability to recognize PXR in immunohistochemical staining and western blotting.

Kreuzreaktivität: Ratte

Aufreinigung: Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Immunogen: Recombinant Pregnane X Receptor (PXR) corresdonding to Tyr205-Gly390 with N-terminal His and GST Tag

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Western blotting: 0.5-2 μg/mL

Immunohistochemistry: 5-20 μg/mL

Immunocytochemistry: 5-20 μg/mL

Optimal working dilutions must be determined by end user.

Kommentare:

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.01M PBS, pH 7.4, containing 0.05 % Proclin-300, 50 % glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 24 months

Referenzen für anti-NR1I2 Antikörper (ABIN1860380)

Huang, Mukherjee, DesMarais, Albanese, Rafti, Draghi Ii, Maher, Khanna, Mani, Matson: "Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis." in: Pediatric research, Vol. 83, Issue 5, pp. 1031-1040, (2018) (PubMed).

Details zu NR1I2

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Andere Bezeichnung: Pregnane X Receptor (NR1I2 Produkte)

Synonyme: BXR antikoerper, ONR1 antikoerper, PAR antikoerper, PAR1 antikoerper, PAR2 antikoerper, PARq antikoerper, PRR antikoerper, PXR antikoerper, SAR antikoerper, SXR antikoerper, PXR.1 antikoerper, PXR.2 antikoerper, PXR1 antikoerper, mPXR antikoerper, bxr antikoerper, nr1i2 antikoerper, onr1 antikoerper, xonr1 antikoerper, nuclear receptor subfamily 1 group I member 2 antikoerper, nuclear receptor subfamily 1, group I, member 2 antikoerper, nuclear receptor subfamily 1 group I member 2 S homeolog antikoerper, NR1I2 antikoerper, Nr1i2 antikoerper, nr1i2.S antikoerper, nr1i2 antikoerper

Hintergrund: NR1I2, SAR, PAR1, PAR2, PRR, BXR, ONR1, PAR, PARq, SXR, Nuclear Receptor Subfamily 1,Group I,Member 2, Steroid and xenobiotic receptor, Pregnane X receptor

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway