COL2A1 Antikörper (Chain alpha 1)

Produktnummer ABIN181162

Produktdetails anti-COL2A1 Antikörper

Target: COL2A1 (Collagen, Type II, alpha 1 (COL2A1))

Bindungsspezifität: Chain alpha 1

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser COL2A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to Collagen II.

Aufreinigung: Purified

Anwendungsinformationen

Applikationshinweise: ELISA. Immunoblotting. Immunofluorescence. Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.4 mg/mL

Buffer: Borate buffered saline

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu COL2A1

Target: COL2A1 (Collagen, Type II, alpha 1 (COL2A1))

Abstract: COL2A1 Produkte

Synonyme: ANFH antikoerper, AOM antikoerper, COL11A3 antikoerper, SEDC antikoerper, Col2 antikoerper, Col2a antikoerper, Col2a-1 antikoerper, Del1 antikoerper, Dmm antikoerper, Lpk antikoerper, M100856 antikoerper, Rgsc856 antikoerper, CG2A1A antikoerper, COLLII antikoerper, col2a1a antikoerper, CB11 antikoerper, col2a1 antikoerper, coll2a1 antikoerper, fb38c06 antikoerper, fc10c01 antikoerper, wu:fb38c06 antikoerper, wu:fc10c01 antikoerper, collagen type II alpha 1 chain antikoerper, collagen, type II, alpha 1 antikoerper, collagen, type II, alpha 1 L homeolog antikoerper, collagen, type II, alpha 1 S homeolog antikoerper, collagen, type II, alpha 1a antikoerper, COL2A1 antikoerper, Col2a1 antikoerper, col2a1 antikoerper, col2a1.L antikoerper, col2a1.S antikoerper, col2a1a antikoerper

Hintergrund: Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three dimensional epitopes. This may result in diminished reactivity of some antibodies with denatured collagen or formalin fixed, paraffin embedded tissues. Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.Synonyms: Alpha-1 type II collagen, COL2A1

Gen-ID: 1280

NCBI Accession: NP_001835

UniProt: P02458

Pathways: Sensory Perception of Sound, Growth Factor Binding