ATP2C1 Antikörper
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- Target Alle ATP2C1 Antikörper anzeigen
- ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))
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Reaktivität
- Human, Affe
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser ATP2C1 Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of ATP2C1 expressed in E. coli.
- Klon
- 4G12
- Isotyp
- IgG1
- Top Product
- Discover our top product ATP2C1 Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." in: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).
: "ATP2C1 gene mutation analysis in Italian patients with Hailey-Hailey disease." in: The Journal of investigative dermatology, Vol. 125, Issue 5, pp. 933-5, (2005) (PubMed).
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Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." in: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).
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- Target
- ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))
- Andere Bezeichnung
- ATP2C1 (ATP2C1 Produkte)
- Synonyme
- ATP2C1 antikoerper, ATP2C1A antikoerper, BCPM antikoerper, HHD antikoerper, PMR1 antikoerper, SPCA1 antikoerper, hSPCA1 antikoerper, Spca1 antikoerper, si:dkey-11p23.6 antikoerper, SPCA antikoerper, 1700121J11Rik antikoerper, AW061228 antikoerper, D930003G21Rik antikoerper, pmr1 antikoerper, ATPase secretory pathway Ca2+ transporting 1 antikoerper, ATPase, Ca++ transporting, type 2C, member 1 antikoerper, ATPase, Ca++-sequestering antikoerper, ATP2C1 antikoerper, atp2c1 antikoerper, Atp2c1 antikoerper
- Hintergrund
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Description: ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
Aliases: HHD, BCPM, PMR1, SPCA1
- Molekulargewicht
- 100 kDa
- Gen-ID
- 27032
- HGNC
- 27032
- Pathways
- Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process
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