Atic/Aicar Transformylase (AA 351-450) Antikörper
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- Target
- Atic/Aicar Transformylase
- Bindungsspezifität
- AA 351-450
- Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
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Konjugat
- Unkonjugiert
- Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Kreuzreaktivität
- Human
- Homologie
- Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human ATIC/AICAR transformylase
- Isotyp
- IgG
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-
- Applikationshinweise
-
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- Atic/Aicar Transformylase
- Hintergrund
-
Synonyms: 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase, 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase, 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR, AICAR formyltransferase/IMP cyclohydrolase bunctional enzyme, AICAR transformylase, AICARFT, AICARFT/IMPCHASE, ATIC, Bunctional purine biosynthesis protein PURH, FLJ93545, IMP cyclohydrolase, IMP synthase, IMP synthetase, IMPCHASE, Inosinicase, OK/SW-cl.86, Phosphoribosylaminoimidazolecarboxamide formyltransferase, Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase, PUR9_HUMAN, PURH.
Background: The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease.
- Gen-ID
- 471
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