GABPA Antikörper (AA 51-150)

Produktnummer ABIN1714176

Produktdetails anti-GABPA Antikörper

Target: GABPA (GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA))

Bindungsspezifität: AA 51-150

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GABPA/NRF2A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-GABPA Antikörper (ABIN1714176)

Chang, Wu, Xu, Liao, Wu, Cheng: "Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation." in: Molecules (Basel, Switzerland), Vol. 20, Issue 2, pp. 2786-801, (2015) (PubMed).

Details zu GABPA

Target: GABPA (GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA))

Andere Bezeichnung: GABPA/NRF2A (GABPA Produkte)

Synonyme: gabpa-A antikoerper, XrpFI antikoerper, X-alpha1 antikoerper, GABPA antikoerper, nft2 antikoerper, nrf2 antikoerper, nrf2a antikoerper, e4tf1a antikoerper, e4tf1-60 antikoerper, Nrf-2alpha antikoerper, Nrf2a antikoerper, E4TF1-60 antikoerper, E4TF1A antikoerper, NFT2 antikoerper, NRF2 antikoerper, NRF2A antikoerper, RCH04A07 antikoerper, GABPalpha antikoerper, e4tf antikoerper, wu:fc12d11 antikoerper, GA binding protein transcription factor alpha subunit S homeolog antikoerper, GA binding protein transcription factor alpha subunit antikoerper, GA binding protein transcription factor, alpha subunit antikoerper, GA binding protein transcription factor alpha subunit L homeolog antikoerper, GA repeat binding protein, alpha antikoerper, gabpa.S antikoerper, GABPA antikoerper, gabpa antikoerper, Gabpa antikoerper, gabpa.L antikoerper

Hintergrund:

Synonyms: E4TF 1A, E4TF1 60, E4TF1A, GA binding protein alpha chain, GA binding protein transcription factor alpha subunit 60 kDa, GA binding protein transcription factor alpha subunit, GA-binding protein alpha chain, GABP A, GABP alpha subunit, GABP alpha subunit, GABP subunit alpha, Gabpa, GABPA_HUMAN, Human nuclear respiratory factor 2 subunit alpha, NFT 2, NFT2, NRF 2, NRF 2A, NRF2, NRF2A, Nuclear respiratory factor 2 alpha subunit, Nuclear respiratory factor 2 subunit alpha, Nuclear respiratory factor 2 subunit alpha, RCH04A07, Transcription factor E4TF1 60, Transcription factor E4TF1 60, Transcription factor E4TF1-60.

Background: The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-alpha and a GABP-alpha-associated subunit, GABP beta. GABP alpha binds to a specific DNA sequence and GABP beta exists as b1 and b2 splice variants that differ in their C-termini. In primary neuronal cultures, GABP beta is expressed in both the cytoplasm and the nucleus, whereas GABP alpha is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABP alpha beta heterodimer or a GABP alpha b heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo. The GABP alpha beta tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription.

Gen-ID: 2551

Pathways: Myometrial Relaxation and Contraction