Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kDa (CSTF3) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704168
Antigen
  • cstf3
  • MGC76035
  • CSTF3
  • wu:fa99c02
  • wu:fb18b09
  • zgc:56028
  • 4732468G05Rik
  • C79532
  • CstF-77
  • cstf3a
  • CSTF-77
  • cleavage stimulation factor, 3' pre-RNA, subunit 3
  • cleavage stimulation factor subunit 3
  • cstf3
  • CSTF3
  • LOC100544392
  • LOC100641283
  • Cstf3
  • cstf3.S
Reaktivität
Human, Maus, Ratte (Rattus)
79
28
27
9
7
7
6
6
4
4
2
2
1
1
Wirt
Kaninchen
61
14
4
Klonalität
Polyklonal
Konjugat
Cy5
5
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
60
34
12
8
5
5
3
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human CSTF3/CSTF77
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Cstf3/Cstf77 (CSTF3 Antibody Abstract)
Hintergrund

Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. Heterotrimeric CstF recognizes GU- and U-rich sequences located downstream of the polyadenylation site on RNA. CstF-77 (cleavage stimulation factor, 77 kDa subunit), also known as CstF3, is one of the three subunits comprising CstF. It can exist as a homodimer and functions as the bridge, directly interacting with the other two CstF subunits, namely CstF-64 and CstF-50. CstF-77 is highly conserved among eukaryotes. It contains an Alpha-helical structure with 11 HAT (Half-a-TPR-containing) repeats and is essential for CstF assembly. In addition, CstF-77 is capable of interacting with CPSF1 and FCP1, other factors involved in polyadenylation.

Synonyms: CF 1 77 kDa subunit, Cleavage stimulation factor 77 kDa subunit, Cleavage stimulation factor subunit 3, Cleavage stimulation factor subunit 3 isoform 1, CSTF 3, CSTF 77, CSTF 77 kDa subunit, CSTF77, MGC117398, MGC43001, MGC75122, CSTF3_HUMAN.

Gen-ID 1479
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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