SARS-CoV NSP3 Antikörper (AA 761-860) (Biotin)

Produktnummer ABIN1700372

Produktdetails anti-SARS-CoV NSP3 Antikörper (Biotin)

Target: SARS-CoV NSP3 (SARS-Coronavirus Nonstructural Protein 3 (SARS-CoV NSP3))

Bindungsspezifität: AA 761-860

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SARS-CoV NSP3 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA

Homologie: Human,Mouse,Rat,Dog,Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NSP3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SARS-CoV NSP3

Target: SARS-CoV NSP3 (SARS-Coronavirus Nonstructural Protein 3 (SARS-CoV NSP3))

Andere Bezeichnung: NSP3 (SARS-CoV NSP3 Produkte)

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: Cas/HEF1 associated signal transducer, CHAT, FLJ39664, Novel SH2 containing protein 3, Novel SH2-containing protein 3, NSP 3, PRO34088, SH2 domain containing 3C, SH2 domain containing Eph receptor binding protein 1, SH2 domain containing protein 3C, SH2 domain-containing protein 3C, SH2D3_HUMAN, SH2D3C, Shep1.

Background: Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5).