C4b-A (AA 1301-1400) Antikörper (Alexa Fluor 488)

Produktnummer ABIN1694461

Produktdetails

Target: C4b-A

Bindungsspezifität: AA 1301-1400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Alexa Fluor 488

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C4A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: C4b-A

Synonyme: C4 antikoerper, C4A2 antikoerper, C4A3 antikoerper, C4A4 antikoerper, C4A6 antikoerper, C4AD antikoerper, C4S antikoerper, CO4 antikoerper, CPAMD2 antikoerper, RG antikoerper, complement C4A (Rodgers blood group) antikoerper, C4A antikoerper

Hintergrund:

Synonyms: C4b-A, complement C4-A proprotein, Acidic complement C4, Basic complement C4, CH, Chido blood group, Complement component 4A, Complement component 4B, RG, Rodgers blood group, CO4A_HUMAN, CO4B_HUMAN, C4A, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG.

Background: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

UniProt: P0C0L4