CENPW Antikörper (N-Term)

Produktnummer ABIN1587944

Produktdetails anti-CENPW Antikörper

Target: CENPW (Centromere Protein W (CENPW))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CENPW Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: At least three isoforms of CENPW are known to exist, this antibody will detect all three isoforms.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: CENPW antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CENPW.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CENPW antibody can be used for detection of CENPW by Western blot at 0.5 - 1 μg/mL.

Kommentare:

(NT) Centromere protein W

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: 4 °C

Informationen zur Lagerung: CENPW antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Haltbarkeit: 12 months

Details zu CENPW

Target: CENPW (Centromere Protein W (CENPW))

Andere Bezeichnung: CENPW (CENPW Produkte)

Synonyme: C6orf173 antikoerper, CUG2 antikoerper, 2610036L11Rik antikoerper, Cug2 antikoerper, CENP-W antikoerper, centromere protein W antikoerper, CENPW antikoerper, Cenpw antikoerper

Hintergrund: CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.

Gen-ID: 387103

NCBI Accession: NP_001012525