p39 (C-Term) Antikörper

Produktnummer ABIN1574191

Produktdetails

Target: p39

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: P39 Antibody, pAb, Rabbit detects endogenous levels of human, mouse, and rat p39.Positive Control: HEK293, SH-SY5Y, mouse and rat brain

Kreuzreaktivität (Details): p39 Antibody, pAb, Rabbit detects endogenous levels of human, mouse, and rat p39.Positive Control: HEK293, SH-SY5Y, mouse and rat brain

Aufreinigung: Immunoaffinity chromatography

Immunogen: KLH-coupled synthetic peptide from C-terminal of human p39

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 2-4 µg/mLOther Applications: User optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: p39

Synonyme: AP-1 antikoerper, AP1 antikoerper, c-Jun antikoerper, B230310J22Rik antikoerper, p39 antikoerper, Jun proto-oncogene, AP-1 transcription factor subunit antikoerper, cyclin-dependent kinase 5, regulatory subunit 2 (p39) antikoerper, JUN antikoerper, Jun antikoerper, Cdk5r2 antikoerper

Hintergrund: P35 and p39 are neuronal-specific regulatory subunit of Cyclin-dependent kinase 5 (CDK5). Both p35 and p39 are expressed in the brain and have been implicated in the regulation of the neuronalcytoskeleton and synaptic function via the control of CDK5 activity. N-terminal of p35 and p39 associates with alpha-actinin-1 while CaMKII could bind to the C-terminus of p35 and p39. Association of p39 with CDK5 promotes Munc18-1 phosphorylation and Ca2+-dependent exocytosis. Phosphorylation of p39 by CDK5 plays a role in the regulation of p39/cdk5 kinase.p39 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human p39 (Swiss Prot: Q13319).