EEA1 Antikörper (N-Term)

Produktnummer ABIN1574158

Produktdetails anti-EEA1 Antikörper

Target: EEA1 (Early Endosome Antigen 1 (EEA1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EEA1 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Spezifität: Rabbit Anti-EEA1 Polyclonal Antibody detects endogenous levels of human, mouse and rat EEA1 protein.

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: Rabbit Anti-EEA1 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human EEA1 (Swiss Prot: Q15075).

Aufreinigung: Immunoaffinity chromatography

Immunogen: KLH-coupled synthetic peptide from N-terminal of human EEA1

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Konzentration: 0.5 mg/mL

Buffer: Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.

Referenzen für anti-EEA1 Antikörper (ABIN1574158)

Tian, Zhu, Hu, Wang, Huang, Xiao: "Dynamics of exosome internalization and trafficking." in: Journal of cellular physiology, Vol. 228, Issue 7, pp. 1487-95, (2013) (PubMed).

Hazeki, Kametani, Murakami, Uehara, Ishikawa, Nigorikawa, Takasuga, Sasaki, Seya, Matsumoto, Hazeki: "Phosphoinositide 3-kinase? controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages." in: PLoS ONE, Vol. 6, Issue 10, pp. e26836, (2011) (PubMed).

Details zu EEA1

Target: EEA1 (Early Endosome Antigen 1 (EEA1))

Andere Bezeichnung: EEA1 (EEA1 Produkte)

Synonyme: MST105 antikoerper, MSTP105 antikoerper, ZFYVE2 antikoerper, im:7151048 antikoerper, si:ch211-276p10.2 antikoerper, A430109M19Rik antikoerper, B230358H09Rik antikoerper, early endosome antigen 1 antikoerper, early endosome antigen 1 S homeolog antikoerper, EEA1 antikoerper, eea1 antikoerper, Eea1 antikoerper, eea1.S antikoerper

Hintergrund: Early endosomal antigen 1 (EEA1) is an early endosomal marker which is essential for fusion between early endocytic vesicles. It interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion. EEA1 protein contains an N-terminal zinc finger motif and a cys-rich C-terminal metal-binding finger. A FYVE domain located at the carboxy terminus of EEA1 binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes.

Molekulargewicht: Predicted Band Size: 162 KD
Observed Band Size: 162 KD

UniProt: Q15075

Pathways: Toll-Like Receptors Cascades