RAB5 Antikörper (AA 150-200)

Produktnummer ABIN1574080

Produktdetails anti-RAB5 Antikörper

Target: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Bindungsspezifität: AA 150-200

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAB5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Rabbit Anti-Rab5 Polyclonal Antibody detects endogenous levels of human, mouse and rat Rab5 protein.

Aufreinigung: Immunoaffinity chromatography

Immunogen: KLH-coupled synthetic peptide from within AA 150-200 of human Rab5 protein .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

ELISA: 0.05-0.2 µg/mL
Western blot: 0.5-1 µg/mL
Other applications: user-optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Details zu RAB5

Target: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Andere Bezeichnung: Rab5 (RAB5A Produkte)

Synonyme: RAB5 antikoerper, 2410015H04Rik antikoerper, AI663973 antikoerper, AU021172 antikoerper, nnyRab5a antikoerper, DDBDRAFT_0168594 antikoerper, DDBDRAFT_0229401 antikoerper, DDB_0168594 antikoerper, DDB_0229401 antikoerper, rab5 antikoerper, RAB5A antikoerper, Rab5a antikoerper, rab5al antikoerper, zgc:56644 antikoerper, fj38g08 antikoerper, hm:zehn1144 antikoerper, rab5a antikoerper, wu:fj38g08 antikoerper, RAB5A, member RAS oncogene family antikoerper, rab5A protein antikoerper, Rab5a, GTPase antikoerper, predicted protein antikoerper, Rab GTPase antikoerper, RAB5A, member RAS oncogene family L homeolog antikoerper, RAB5A, member RAS oncogene family, b antikoerper, RAB5A, member RAS oncogene family, a antikoerper, RAB5A antikoerper, Rab5a antikoerper, rab5A antikoerper, rab5a antikoerper, rab5a.L antikoerper, rab5ab antikoerper, rab5aa antikoerper

Hintergrund: Small GTPase Rab5 is a member of Rab family which binds to GTP and exhibits GTPase activity. Rab5 protein is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. Rabaptin-5 serves as an effector of Rab5 and mediates the tuberin association with Rab5. RNTRE protein whose activity is regulated by EGFR activates Rab5 GTPase. RNTRE acts on Rab5 and inhibits EGFR's internalization. The ALS2 protein specifically binds to Rab5 and functions as a guanine nucleotide exchange factor (GEF) for Rab5. As a key regulator of endocytosis, signal transduction, and mitogenesis, Rab5 protein is also a signaling GTPase that elucidates the major molecular elements of its downstream pathway.Rabbit Anti-Rab5 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 150-200 of human Rab5 protein (Swiss Prot: P20339).

Pathways: Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity