RYBP Antikörper

Produktnummer ABIN155069

Der Kaninchen Polyklonal anti-RYBP Antikörper wird verwendet zum Nachweis von RYBP in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für RYBP Antikörper (ABIN155069)

Target: RYBP (RING1 and YY1 Binding Protein (RYBP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RYBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RYBP Antikörper

Spezifität: This antibody detects DEDAF. A 32 kDa band should be detected.

Aufreinigung: Affinity purified

Immunogen: Synthetic peptide surrounding amino acid 218 of human DEDAF.

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5-4 μg/mL. A549 or HepG2 cell lysate can be used as a positive control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Details zu RYBP

Target: RYBP (RING1 and YY1 Binding Protein (RYBP))

Andere Bezeichnung: RYBP

Hintergrund: Cell death signal are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA biding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.Synonyms: AAP-1, APAP-1, Apoptin-associating protein 1, DED-associated factor, DEDAF, Death effector domain-associated factor, RING1 and YY1-binding protein, YEAF1, YY1 and E4TF1-associated factor 1

Gen-ID: 23429

NCBI Accession: NP_036366

UniProt: Q8N488