RUVBL1 Antikörper

Produktnummer ABIN2837838

Produktdetails anti-RUVBL1 Antikörper

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RUVBL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody.

Klon: 507CT2-2-2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:100~500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: RUVBL1 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu RUVBL1

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Andere Bezeichnung: RUVBL1 (RUVBL1 Produkte)

Synonyme: rvb1 antikoerper, ecp54 antikoerper, tip49 antikoerper, nmp238 antikoerper, pontin antikoerper, tip49a antikoerper, xpontin antikoerper, pontin52 antikoerper, TIP49 antikoerper, wu:fd18e04 antikoerper, zpontin antikoerper, ECP54 antikoerper, INO80H antikoerper, NMP238 antikoerper, PONTIN antikoerper, Pontin52 antikoerper, RVB1 antikoerper, TIH1 antikoerper, TIP49A antikoerper, Tip49a antikoerper, 2510009G06Rik antikoerper, RuvB like AAA ATPase 1 antikoerper, RuvB-like 1 (E. coli) antikoerper, RuvB-like 1 antikoerper, RuvB like AAA ATPase 1 S homeolog antikoerper, RuvB-like AAA ATPase 1 antikoerper, RuvB-like protein 1 antikoerper, RUVBL1 antikoerper, ruvbl1 antikoerper, PVX_123295 antikoerper, Bm1_15605 antikoerper, ruvb1 antikoerper, ruvbl1.S antikoerper, Ruvbl1 antikoerper

Hintergrund: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.

Molekulargewicht: 50228

Gen-ID: 8607

NCBI Accession: NP_003698

UniProt: Q9Y265

Pathways: Telomere Maintenance