NR1H4 Antikörper (N-Term)

Produktnummer ABIN1539134

Produktdetails anti-NR1H4 Antikörper

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Bindungsspezifität: AA 18-46, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1H4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NR1H4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human NR1H4.

Klon: RB39466

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: NR1H4 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu NR1H4

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Andere Bezeichnung: NR1H4 (NR1H4 Produkte)

Synonyme: zgc:110190 antikoerper, zgc:92742 antikoerper, NR1H4 antikoerper, BAR antikoerper, FXR antikoerper, HRR-1 antikoerper, HRR1 antikoerper, RIP14 antikoerper, AI957360 antikoerper, Fxr antikoerper, Rxrip14 antikoerper, nuclear receptor subfamily 1, group H, member 5 S homeolog antikoerper, nuclear receptor subfamily 1, group H, member 4 antikoerper, nuclear receptor subfamily 1 group H member 4 antikoerper, nr1h5.S antikoerper, nr1h4 antikoerper, NR1H4 antikoerper, Nr1h4 antikoerper

Hintergrund: NR1H4 is a Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

Molekulargewicht: 55914

Gen-ID: 9971

NCBI Accession: NP_001193906, NP_001193907, NP_001193908, NP_001193921, NP_001193922, NP_005114

UniProt: Q96RI1

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process