TACI Antikörper

Produktnummer ABIN1504149

Produktdetails anti-TACI Antikörper

Target: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TACI Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Spezifität: This antibody reacts with CD267 antigen. Clone 11H3 has an agonistic activity and it doesn't block binding of BAFF to TACI.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A agarose

Klon: 11H3

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Details zu TACI

Target: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Andere Bezeichnung: CD267 / TACI (TNFRSF13B Produkte)

Synonyme: CD267 antikoerper, CVID antikoerper, CVID2 antikoerper, RYZN antikoerper, TACI antikoerper, TNFRSF14B antikoerper, TNFRSF13B antikoerper, 1200009E08Rik antikoerper, Taci antikoerper, TNF receptor superfamily member 13B antikoerper, tumor necrosis factor receptor superfamily, member 13b antikoerper, TNFRSF13B antikoerper, Tnfrsf13b antikoerper

Hintergrund: CD267, also known as TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) or TNFRSF13B, is a member of the tumor necrosis factor (TNF) receptor family that serves as a receptor for B-cell activating factor of the TNF family (BAFF/CD257) and as a proliferation-inducing ligand (APRIL/CD256). BAFF and APRIL bind both TACI and BCMA (B cell maturation Ag/CD269), with BAFF additionally and exclusivel y binding the BAFF receptor (BAFF-R/CD268) while APRIL can also bind to heparin sulfate proteoglycan s (HSPG). TACI is expressed on B cells and activated T cells. BC MA is exclusively expressed on B cells, whereas BAFF-R is expressed mainly on B cells but also on T cells. It is reported that mutations of CD267/TACI are showed in patients with IgA deficiency and common variable immunodeficiency (CVID). Sakurai et al ., reported that TACI positively regulated APRIL-induced IgA production in collaboration with HSPG and TACI negatively regulated BAFF-induced B-cell proliferation and production of IgA and IgG.Synonyms: TNFRSF13B, Transmembrane activator and CAML interactor, Tumor necrosis factor receptor superfamily member 13B

Gen-ID: 23495