ANKLE2 Antikörper (Middle Region)

Produktnummer ABIN1449856

Produktdetails anti-ANKLE2 Antikörper

Target: ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANKLE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CYSPSDRQSW PSPAVKGRFK SQLPDLSGPH SYSPGRNSVA GSNPAKPGLG

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the middle region of human KIAA0692

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu ANKLE2

Target: ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))

Andere Bezeichnung: ANKLE2 / KIAA0692 (ANKLE2 Produkte)

Synonyme: KIAA0692 antikoerper, LEMD7 antikoerper, Lem4 antikoerper, 1110001J12Rik antikoerper, AI661024 antikoerper, D5Ertd585e antikoerper, RGD1310191 antikoerper, ankyrin repeat and LEM domain containing 2 antikoerper, ANKLE2 antikoerper, Ankle2 antikoerper

Hintergrund: ANKLE2 or KIAA0692 is a single-pass membrane protein. It contains 1 ANK repeat and 1 LEM domain. It contains 1 RING-type zinc finger. It is involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. ANKLE2 coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.Synonyms: Ankyrin repeat and LEM domain-containing protein 2

Gen-ID: 23141

NCBI Accession: NP_055929