MORC3 Antikörper

Produktnummer ABIN1449250

Produktdetails anti-MORC3 Antikörper

Target: MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MORC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects MORC3.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat

Aufreinigung: Protein A agarose

Immunogen: Recombinant human MORC3

Klon: 17A9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu MORC3

Target: MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))

Andere Bezeichnung: MORC3 (MORC3 Produkte)

Synonyme: NXP2 antikoerper, ZCW5 antikoerper, ZCWCC3 antikoerper, 1110051N18Rik antikoerper, AI452146 antikoerper, BF318192 antikoerper, D16Jhu32e antikoerper, Zcwcc3 antikoerper, sb:cb561 antikoerper, sb:cb69 antikoerper, zgc:101052 antikoerper, fb73c08 antikoerper, wu:fb73c08 antikoerper, zgc:162471 antikoerper, morc3 antikoerper, MORC family CW-type zinc finger 3 antikoerper, microrchidia 3 antikoerper, MORC family CW-type zinc finger 3b antikoerper, MORC family CW-type zinc finger 3a antikoerper, MORC family CW-type zinc finger 3 S homeolog antikoerper, MORC3 antikoerper, Morc3 antikoerper, morc3b antikoerper, morc3a antikoerper, morc3.S antikoerper

Hintergrund: MORC3 { m icr orc hidia (MORC) family CW-type zinc finger 3 , KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conser ved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al . reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.Synonyms: KIAA0136, MORC family CW-type zinc finger protein 3, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3

Gen-ID: 23515

NCBI Accession: NP_056173

UniProt: Q14149

Pathways: Maintenance of Protein Location