Peroxiredoxin 2 Antikörper (AA 131-198) (Cy5)
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- Target Alle Peroxiredoxin 2 (PRDX2) Antikörper anzeigen
- Peroxiredoxin 2 (PRDX2)
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Bindungsspezifität
- AA 131-198
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Peroxiredoxin 2 Antikörper ist konjugiert mit Cy5
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Dog,Cow,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Peroxiredoxin-2
- Isotyp
- IgG
- Top Product
- Discover our top product PRDX2 Primärantikörper
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- Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Peroxiredoxin 2 (PRDX2)
- Andere Bezeichnung
- Peroxiredoxin 2 (PRDX2 Produkte)
- Synonyme
- NKEF-B antikoerper, NKEFB antikoerper, PRP antikoerper, PRX2 antikoerper, PRXII antikoerper, PTX1 antikoerper, TDPX1 antikoerper, TPX1 antikoerper, TSA antikoerper, AL022839 antikoerper, Band-8 antikoerper, NkefB antikoerper, PrxII antikoerper, TDX1 antikoerper, TPx antikoerper, TPx-B antikoerper, TR antikoerper, Tdpx1 antikoerper, Torin antikoerper, nkefb antikoerper, prx-2 antikoerper, prx2 antikoerper, prxii antikoerper, tdpx1 antikoerper, tpx1 antikoerper, peroxiredoxin 2 antikoerper, peroxiredoxin 2 L homeolog antikoerper, PRDX2 antikoerper, Prdx2 antikoerper, prdx2.L antikoerper
- Hintergrund
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Synonyms: MGC4104, Natural killer cell enhancing factor B, Natural killer cell-enhancing factor B, Natural Killer Enhancing Factor B, NKEF B, NKEF-B, NKEFB, Peroxiredoxin-2, PRDX 2, PRDX2, PRDX2_HUMAN, PRP, PRX2, PRXII, TDPX1, Thiol Specic Antioxidant 1, Thiol specic antioxidant protein, Thiol-specic antioxidant protein, Thioredoxin Dependent Peroxide Reductase 1, Thioredoxin Peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Torin, TPX1, TSA.
Background: Peroxiredoxin (Prx) is an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at the active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Peroxiredoxin 1 to 4 have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Peroxiredoxin 1. The active site cysteine(Cys51) is oxidized to cysteine sulfenic acid(Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from the other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress conditions, the sulfenic intermediate(Cys51-SOH) can be easily over oxidized to cysteine sulfinic acid(Cys-SO2H) or cysteine sulfonic acid(Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that over oxidized Prx can be reduced back to the active form during recovery after oxidative stress.
- Gen-ID
- 7001
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