Proteoglycan 4 Antikörper (AA 1151-1250) (Cy5)
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- Target Alle Proteoglycan 4 (PRG4) Antikörper anzeigen
- Proteoglycan 4 (PRG4)
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Bindungsspezifität
- AA 1151-1250
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Reaktivität
- Maus, Ratte, Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Proteoglycan 4 Antikörper ist konjugiert mit Cy5
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Kreuzreaktivität
- Maus, Kaninchen, Ratte
- Homologie
- Human,Dog,Cow
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Lubricin/SZP
- Isotyp
- IgG
- Top Product
- Discover our top product PRG4 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Proteoglycan 4 (PRG4)
- Andere Bezeichnung
- Lubricin/SZP (PRG4 Produkte)
- Synonyme
- CACP antikoerper, HAPO antikoerper, JCAP antikoerper, MSF antikoerper, SZP antikoerper, bG174L6.2 antikoerper, lubricin antikoerper, prg4 antikoerper, si:dkey-97o5.3 antikoerper, zgc:122988 antikoerper, PRG4 antikoerper, DOL54 antikoerper, proteoglycan 4 antikoerper, proteoglycan 4b antikoerper, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) antikoerper, PRG4 antikoerper, Prg4 antikoerper, prg4b antikoerper
- Hintergrund
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Synonyms: Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2, CACP, camptodactyly arthropathy coxa vara pericarditis syndrome gene, FLJ32635, HAPO, Jacobs camptodactyly-arthropathy-pericarditis syndrome gene, JCAP, megakaryocyte stimulating factor, MSF, PRG 4, PRG4, proteoglycan 4, Proteoglycan4, Superficial zone proteoglycan, SZP.
Background: Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights.
- Gen-ID
- 10216
- UniProt
- Q92954
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