CLEC11A Antikörper (Biotin)

Produktnummer ABIN1405339

Produktdetails anti-CLEC11A Antikörper (Biotin)

Target: CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLEC11A Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Pleckstrin/p47

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CLEC11A

Target: CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))

Andere Bezeichnung: p47 (CLEC11A Produkte)

Synonyme: CLEC11A antikoerper, CLECSF3 antikoerper, LSLCL antikoerper, P47 antikoerper, SCGF antikoerper, AW457320 antikoerper, Clecsf3 antikoerper, Scgf antikoerper, C-type lectin domain containing 11A antikoerper, C-type lectin domain family 11, member a antikoerper, CLEC11A antikoerper, Clec11a antikoerper

Hintergrund:

Synonyms: p47, Platelet 47 kDa protein, Platelet and leukocyte C kinase substrate, Platelet P47, Platelet p47 protein, Pleckstrin, PLEK, PLEK_HUMAN, FLJ27168, OTTHUMP00000159962.

Background: Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89 % sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.

Gen-ID: 5341