Paralemmin Antikörper (AA 130-230) (Biotin)

Produktnummer ABIN1394785

Produktdetails anti-Paralemmin Antikörper (Biotin)

Target: Paralemmin (PALM)

Bindungsspezifität: AA 130-230

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Paralemmin Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Paralemmin 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Paralemmin

Target: Paralemmin (PALM)

Andere Bezeichnung: Paralemmin 1 (PALM Produkte)

Synonyme: PALM antikoerper, palm antikoerper, zgc:110136 antikoerper, paralemmin antikoerper, paralemmin 1a antikoerper, paralemmin S homeolog antikoerper, PALM antikoerper, palm1a antikoerper, palm antikoerper, palm.S antikoerper, Palm antikoerper

Hintergrund:

Synonyms: KIAA0270, PALM, PALM_HUMAN, Paralemmin, Paralemmin1,Paralemmin-1.

Background: Paralemmin, also called Paralemmin-1 or PALM, is a widely expressed peripheral membrane protein that is involved in cell structure and shape. A hydrophobic protein, Paralemmin is anchored to the cytoplasmic side of the cell membrane via di-palmitoylation and prenylation of its C-terminal cysteine cluster. Functioning at the synapse to regulate neuronal plasticity and plasma membrane dynamics, Paralemmin can bind to the dopamine receptor D3, thereby reducing D3 expression and subsequent adenylate cyclase activity. Overexpression of Paralemmin induces fibroblasts to extend long filopodia and to assume extreme cell shapes, suggesting involvement in the formation and stabilization of the plasma membrane. Two isoforms of Paralemmin exists due to alternative splicing events.

Pathways: cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling