FEZ2 Antikörper (AA 165-240) (Biotin)

Produktnummer ABIN1393639

Produktdetails anti-FEZ2 Antikörper (Biotin)

Target: FEZ2 (Fasciculation and Elongation Protein zeta 2 (Zygin II) (FEZ2))

Bindungsspezifität: AA 165-240

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FEZ2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FEZ2/Zygin2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu FEZ2

Target: FEZ2 (Fasciculation and Elongation Protein zeta 2 (Zygin II) (FEZ2))

Andere Bezeichnung: FEZ2/Zygin2 (FEZ2 Produkte)

Synonyme: HUM3CL antikoerper, 9030616F16 antikoerper, D17Ertd315e antikoerper, Zrp antikoerper, fasciculation and elongation protein zeta 2 antikoerper, fasciculation and elongation protein zeta 2 (zygin II) antikoerper, FEZ2 antikoerper, Fez2 antikoerper

Hintergrund:

Synonyms: Fasciculation and elongation protein zeta 2, Fasciculation and elongation protein zeta-2 , FEZ 2, Fez2, FEZ2_HUMAN, Highly similar to zyginII, HUM3CL, MGC117372, Pre T/NK cell associated protein, Zygin 2, Zygin II, Zygin-2.

Background: Zygin 2 is a 353 amino acid cytoplasmic protein that belongs to the zygin family. Zygin 2 is found as a difulfide-linked homodimer but may for heterodimers with FEZ1. the plasma membrane to the cytoplasm by activation of PKC zeta. PKC zeta also enhances zygin 1 interaction with UFD2 and polyubiquitination. Expressed mainly in brain, zygin 1 is a mammalian ortholog of Caenorhabditis elegans UNC-76 and is able to restore partial locomotion and axonal fasciculation to C. elegans UNC-76 mutants, which suggest a functional role in axonal outgrowth. As component of the network of molecules that regulate cellular morphology and axon guidance machinery, zygin 1 may also be involved in microtubule associated transport and transcriptional regulation. Mutations in the gene encoding zygin 1 may be linked to the pathogenesis of schizophrenia. Zygin 1 exists as two alternatively spliced isoforms that are designated isoform long and isoform short.