APBA2 Antikörper (AA 351-450) (Alexa Fluor 647)

Produktnummer ABIN1392534

Produktdetails anti-APBA2 Antikörper (Alexa Fluor 647)

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Bindungsspezifität: AA 351-450

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APBA2 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Sheep,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APBA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu APBA2

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Andere Bezeichnung: APBA2 (APBA2 Produkte)

Synonyme: MGC83599 antikoerper, D15S1518E antikoerper, HsT16821 antikoerper, LIN-10 antikoerper, MGC:14091 antikoerper, MINT2 antikoerper, X11-BETA antikoerper, X11L antikoerper, X11-like antikoerper, XllL antikoerper, mXllL antikoerper, Mint2 antikoerper, amyloid beta precursor protein binding family A member 2 antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 2 L homeolog antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 2 antikoerper, APBA2 antikoerper, apba2.L antikoerper, Apba2 antikoerper

Hintergrund:

Synonyms: Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, APBA2, APBA2_HUMAN, D15S1518E, HsT16821, LIN 10, Mint 2, Mint-2, Neuron-specic X11L protein, Neuronal Munc18-1-interacting protein 2, Phosphotyrosine binding/interacting domain PTB bearing protein, X11 beta, X11l.

Background: The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer?s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the -Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3).

Pathways: Synaptic Vesicle Exocytosis