APBB3 Antikörper (AA 401-486) (Alexa Fluor 350)

Produktnummer ABIN1392447

Produktdetails anti-APBB3 Antikörper (Alexa Fluor 350)

Target: APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))

Bindungsspezifität: AA 401-486

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APBB3 Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APBB3/FE65L2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu APBB3

Target: APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))

Andere Bezeichnung: APBB3/FE65L2 (APBB3 Produkte)

Synonyme: Fe65l2 antikoerper, Rirl2 antikoerper, TR2S antikoerper, MGC142933 antikoerper, FE65L2 antikoerper, SRA antikoerper, amyloid beta (A4) precursor protein-binding, family B, member 3 antikoerper, steroid receptor RNA activator 1 antikoerper, amyloid beta precursor protein binding family B member 3 antikoerper, Apbb3 antikoerper, SRA1 antikoerper, APBB3 antikoerper, apbb3 antikoerper

Hintergrund:

Synonyms: Amyloid beta A4 precursor protein binding family B member 3, Amyloid beta A4 precursor protein-binding family B member 3, amyloid beta precursor protein binding family B member 3, amyloid precursor interacting protein, Apbb3, APBB3_HUMAN, Fe65 like protein 2, FE65L2, Protein Fe65-like 2, SRA.

Background: Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the -Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of -Amyloid. Via its ability to control the intracellular accumulation of -Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6 % of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Gen-ID: 10307

UniProt: O95704