OTX1 Antikörper (AA 1-100) (Alexa Fluor 647)

Produktnummer ABIN1392210

Produktdetails anti-OTX1 Antikörper (Alexa Fluor 647)

Target: OTX1 (Orthodenticle Homeobox 1 (OTX1))

Bindungsspezifität: AA 1-100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTX1 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OTX1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu OTX1

Target: OTX1 (Orthodenticle Homeobox 1 (OTX1))

Andere Bezeichnung: OTX1 (OTX1 Produkte)

Synonyme: A730044F23Rik antikoerper, jv antikoerper, OTX1X antikoerper, cb769 antikoerper, fj99f05 antikoerper, otx1 antikoerper, wu:fj99f05 antikoerper, zOtx1 antikoerper, otx1-A antikoerper, xotx1 antikoerper, otx1l antikoerper, otx3 antikoerper, orthodenticle homeobox 1 antikoerper, orthodenticle homeobox 1b antikoerper, orthodenticle homeobox 1 L homeolog antikoerper, orthodenticle homeobox 1a antikoerper, OTX1 antikoerper, Otx1 antikoerper, otx1b antikoerper, otx1.L antikoerper, otx1a antikoerper

Hintergrund:

Synonyms: Homeobox protein OTX 1, Homeobox protein OTX1, MGC15736, Orthodenticle 1, Orthodenticle homeobox 1, Orthodenticle homolog 1, Orthodenticle1, Otx 1, otx1, OTX1_HUMAN.

Background: Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p15 and 14q21-q22, respectively.