HAS2 Antikörper (Alexa Fluor 350)

Produktnummer ABIN1390389

Produktdetails anti-HAS2 Antikörper (Alexa Fluor 350)

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAS2 Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HAS2/Hyaluronan synthase 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu HAS2

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Andere Bezeichnung: Has2 (HAS2 Produkte)

Synonyme: DG42 antikoerper, XHas2 antikoerper, Has2 antikoerper, hyaluronan synthase 2 antikoerper, hyaluronan synthase 2 S homeolog antikoerper, has2 antikoerper, HAS2 antikoerper, Has2 antikoerper, SHAS2 antikoerper, has2.S antikoerper

Hintergrund:

Synonyms: HA synthase 2, has2, HAS2_HUMAN, Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2.

Background: HAS1, HAS2 and HAS3 are HA Synthase proteins that synthesize HA (Hyaluronan or hyaluronic acid). The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by i²-1,3 and i²-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesise high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli suggesting distinct functional roles of the three proteins. HAS2 mRNA shows predominant expression in chondrocytes and cartilage. The human HAS2 gene maps to chromosome 8q24.12.

Pathways: Glycosaminoglycan Metabolic Process