HFE2 Antikörper (AA 205-255)
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- Target Alle HFE2 Antikörper anzeigen
- HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
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Bindungsspezifität
- AA 205-255
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HFE2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule C
- Isotyp
- IgG
- Top Product
- Discover our top product HFE2 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
- Andere Bezeichnung
- RGMC/Repulsive Guidance Molecule C (HFE2 Produkte)
- Synonyme
- HFE2A antikoerper, HJV antikoerper, JH antikoerper, RGMC antikoerper, HFE2 antikoerper, DKFZp468F2322 antikoerper, 2310035L15Rik antikoerper, 5230400G09Rik antikoerper, AI414844 antikoerper, AI789733 antikoerper, DL-M antikoerper, Rgmc antikoerper, hemojuvelin antikoerper, RGMr antikoerper, hjv antikoerper, id:ibd3464 antikoerper, wu:fb38f10 antikoerper, zgc:136698 antikoerper, hemochromatosis type 2 (juvenile) antikoerper, hemochromatosis type 2 antikoerper, HFE2 antikoerper, Hfe2 antikoerper, hfe2 antikoerper
- Hintergrund
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Synonyms: DL M, Haemojuvelin, HEMOCHROMATOSIS, HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN, HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE, HEMOCHROMATOSIS JUVENILE, Hemochromatosis type 2 juvenile, Hemochromatosis type 2, Hemochromatosis type 2 protein, Hemochromatosis type 2 protein homolog, HEMOCHROMATOSIS, TYPE 2A, HEMOCHROMATOSIS, TYPE 2B, Hemojuvelin, HFE 2, Hfe2, HFE2A, HJV, JH, Juvenile, MGC23953, Repulsive guidance molecule c, RGM C, RGM domain family member C, RGMC, RGMC_HUMAN.
Background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).
- Pathways
- Transition Metal Ion Homeostasis
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