CELSR3 Antikörper (AA 1601-1700)

Produktnummer ABIN1387763

Produktdetails anti-CELSR3 Antikörper

Target: CELSR3 (Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3))

Bindungsspezifität: AA 1601-1700

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CELSR3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Flamingo homolog 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CELSR3 Antikörper (ABIN1387763)

Su, Zhang, Gan, Jiang, Xiao, Zou, Li, Jiang: "Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." in: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).

Details zu CELSR3

Target: CELSR3 (Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3))

Andere Bezeichnung: CELSR3/Flamingo homolog 1 (CELSR3 Produkte)

Synonyme: CDHF11 antikoerper, EGFL1 antikoerper, FMI1 antikoerper, HFMI1 antikoerper, MEGF2 antikoerper, RESDA1 antikoerper, Megf2 antikoerper, Fmi1 antikoerper, flamingo antikoerper, mKIAA0812 antikoerper, cadherin EGF LAG seven-pass G-type receptor 3 antikoerper, cadherin, EGF LAG seven-pass G-type receptor 3 antikoerper, CELSR3 antikoerper, Celsr3 antikoerper

Hintergrund:

Synonyms: Cadherin EGF LAG seven-pass G-type receptor 3, Cadherin family member 11, CDHF11, CELR3_HUMAN, CELSR3, EGF-like protein 1, EGFL1, Epidermal growth factor-like protein 1, Flamingo, Flamingo homolog 1, FMI1, HFMI1, MEGF2, Multiple EGF-like domains protein 2, Multiple epidermal growth factor-like domains protein 2.

Background: Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons.

Gen-ID: 1951

UniProt: Q9NYQ7