Sca-1/Ly-6A/E Antikörper

Produktnummer ABIN133910

Produktdetails anti-Sca-1/Ly-6A/E Antikörper

Target: Sca-1/Ly-6A/E (Ly6a) (Lymphocyte Antigen 6 Complex, Locus A (Ly6a))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Sca-1/Ly-6A/E Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Spezifität: Mouse Sca-1

Aufreinigung: Purified from ascitic fluid via Protein G Chromatography

Isotyp: IgG2b

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/ml

Buffer: Purified Ig buffered in PBS and 0.02% NaN3 (Purified from ascites via Protein G Chromatography).

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-Sca-1/Ly-6A/E Antikörper (ABIN133910)

Sin, Puccini, Huang, Konstandin, Gilbert, Sussman, Gottlieb, Feuer: "The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development." in: PLoS pathogens, Vol. 10, Issue 7, pp. e1004249, (2015) (PubMed).

Details zu Sca-1/Ly-6A/E

Target: Sca-1/Ly-6A/E (Ly6a) (Lymphocyte Antigen 6 Complex, Locus A (Ly6a))

Andere Bezeichnung: Sca-1 (Ly6a Produkte)

Synonyme: Ly-6A.2 antikoerper, Ly-6A/E antikoerper, Ly-6E.1 antikoerper, Sca-1 antikoerper, Sca1 antikoerper, TAP antikoerper, lymphocyte antigen 6 complex, locus A antikoerper, Ly6a antikoerper

Hintergrund: Monoclonal antibody recognizes Sca-1 (Ly-6A.2/6E.1), a cell surface antigen used in the identification of hematopoietic stem cells. It is a member of the Ly-6 antigen family. The Thy-1 lo , Lin (lineage-negative, not expressing B220, Gr-1, Mac-1, CD4 or CD8), Sca-1 population of bone marrow cells are highly purified, perhaps homogenous, pluripotent stem cells. This antigen is also present on various other tissues. Specific staining of the parenchymal cells can be demonstrated in thymus, spleen and kidney where as only vasculature reacts with anti-Sca- 1 in brain, heart and liver (and possibly in lung). Also, Sca-1 is a T cell activation antigen, as surface expression of the antigen increases upon Con A activation of T lymphocytes. Sca-1 appears to have a molecular mass of 8 kDa under non-reducing conditions and 18 kDa under reducing conditions, indicating the presence of intra-chain disulfide bonds.

Pathways: Sensory Perception of Sound, Activated T Cell Proliferation