NCAPH Antikörper (AA 440-457)

Produktnummer ABIN129615

Produktdetails anti-NCAPH Antikörper

Target: NCAPH (Non-SMC Condensin I Complex, Subunit H (NCAPH))

Bindungsspezifität: AA 440-457

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCAPH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 440-457 of Human BRRN-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 83 kDa in size corresponding to human BRRN1 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.93 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu NCAPH

Target: NCAPH (Non-SMC Condensin I Complex, Subunit H (NCAPH))

Andere Bezeichnung: BRRN-1 (NCAPH Produkte)

Synonyme: NCAPH antikoerper, si:dkeyp-86b9.4 antikoerper, zgc:158618 antikoerper, BRRN1 antikoerper, CAP-H antikoerper, brrn1 antikoerper, cap-h antikoerper, A730011O11Rik antikoerper, Brrn1 antikoerper, HCAP-H antikoerper, mKIAA0074 antikoerper, non-SMC condensin I complex subunit H antikoerper, non-SMC condensin I complex, subunit H antikoerper, condensin complex subunit 2 antikoerper, non-SMC condensin I complex subunit H S homeolog antikoerper, NCAPH antikoerper, ncaph antikoerper, LOC708975 antikoerper, ncaph.S antikoerper, Ncaph antikoerper

Hintergrund: BRNN1, also called Barren, Condensin subunit 2, Barren homolog protein 1, Chromosome-associated protein H, hCAP-H, and XCAP-H homolog, is encoded by a gene that is a member of the barr gene family.  Brnn1 is the regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.   The condensin complex contains the SMC2L1 and SMC4L1 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.   BRRN1 has both a nuclear and cytoplasmic localization.  In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2 leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. BRRN1 is widely expressed at low level in most proliferating cells.  CDC2 phosphorylates BRRN1.  Its phosphorylation, as well as that of CNAP1 and CAPG subunits, activates the condensin complex and is required for chromosome condensation.
Synonyms: Barren Drosophila Homolog of 1 antibody, Barren homolog protein 1 antibody, BRRN antibody, CAP H antibody, CAPH antibody, Chromosome associated protein H antibody, Condensin complex subunit 2 antibody, Condensin subunit 2 antibody

Gen-ID: 23397

UniProt: Q15003