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SKG1 Antikörper (Suppressor of lethality of KEX2 GAS1 double null mutant protein 1 ) AA 419-431 Primary Antibody

SKG1 Reaktivität: Human IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN129525
$633.00
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
500 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target See all SKG1 products
    SKG1
    Bindungsspezifität
    AA 419-431
    Reaktivität
    Human
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    SKG-1 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 419-431 of human SGK -1.
    Isotyp
    IgG
  • Applikationshinweise
    SKG-1 Antibody antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~49 kDa in size corresponding to SGK-1 by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    5.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Target
    SKG1
    Andere Bezeichnung
    SKG-1 (SKG1 Produkte)
    Synonyme
    YKR099C-A, Suppressor of lethality of KEX2 GAS1 double null mutant protein 1, SKG1
    Hintergrund
    SGK-1 (also called Serine/threonine-protein kinase Sgk1 and Serum/glucocorticoid-regulated kinase 1) is a protein kinase that plays an important role in cellular stress response.  SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. This kinase mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A and phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1. SGK1 is localized to the cytoplasm and upon phosphorylation is translocated to the nucleus.  The kinase is expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung.  Induction occurs upon exposure to glucocorticoids and by excessive extracellular glucose or TGF-beta, in cultured cells.   SGK-1 is regulated by phosphorylation.  Phosphoinositide 3-kinase (PI3-kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1. The kinase is ubiquitinated by NEDD4L; which promotes proteasomal degradation.
    Synonyms: Serum/glucocorticoid-regulated kinase 1, SGK1 antibody, Cellular stress response antibodies, Serine/threonine-protein kinase Sgk1
    Gen-ID
    6446
    UniProt
    O00141
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