No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Konservierungsmittel
Azide free
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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Bennett, Luxenberg, Ling, Wang, Marquette, Lowe, Khan, Veldman, Jacobs, Valge-Archer, Collins, Carreno: "Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 711-8, (2003) (PubMed).
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Carter, Fouser, Jussif, Fitz, Deng, Wood, Collins, Honjo, Freeman, Carreno: "PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2." in: European journal of immunology, Vol. 32, Issue 3, pp. 634-43, (2002) (PubMed).
Latchman, Wood, Chernova, Chaudhary, Borde, Chernova, Iwai, Long, Brown, Nunes, Greenfield, Bourque, Boussiotis, Carter, Carreno, Malenkovich, Nishimura, Okazaki, Honjo, Sharpe, Freeman: "PD-L2 is a second ligand for PD-1 and inhibits T cell activation." in: Nature immunology, Vol. 2, Issue 3, pp. 261-8, (2001) (PubMed).
Target
PDCD1LG2
(Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
The MIH18 monoclonal antibody specifically binds to CD273, the Programmed Death Ligand 2 (PD-L2). PD-L1 and PD-L2 are newly discovered members of the B7 family that are the ligands for the Programmed Death 1 (PD-1) receptor. They are expressed on immature dendritic cells and mature dendritic cells. PD-L1 is expressed on antigen-presenting cells, including IFN-g-stimulated monocytes and activated human and mouse dendritic cells. Monoclonal antibodies that block PD- 1 and PD-L2 on dendritic cells result in enhanced T cell proliferation and cytokine production. PD-L2, also called B7-DC, is expressed on placental trophoblasts, myocardial endothelium and medullary thymic epithelial cells. Studies show overlapping functions of PD-L1 and PD-L2 and indicate an important role for the PD-L:PD-1 pathway in regulating T cell responses. Synonyms: PDCD1LG2, PDCD1 ligand 2, PDCD1L2, PD-1 ligand 2, PD-L2, PDL2, B7-DC, Btdc