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ERK2 Antikörper (Alexa Fluor 647)

MAPK1 Reaktivität: Human, Maus ICS Wirt: Maus Monoclonal G263-7 Alexa Fluor 647
Produktnummer ABIN1176893
  • Target Alle ERK2 (MAPK1) Antikörper anzeigen
    ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
    Reaktivität
    • 134
    • 72
    • 69
    • 14
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 98
    • 34
    • 4
    • 3
    • 1
    Maus
    Klonalität
    • 89
    • 52
    Monoklonal
    Konjugat
    • 89
    • 11
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser ERK2 Antikörper ist konjugiert mit Alexa Fluor 647
    Applikation
    • 102
    • 65
    • 41
    • 30
    • 24
    • 24
    • 14
    • 9
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intracellular Staining (ICS)
    Marke
    BD Phosflow™
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human ERK2 Synthetic Peptide
    Klon
    G263-7
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product MAPK1 Primärantikörper
  • Probenmenge
    20 μL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
  • Sivaraman, Wang, Nuovo, Malbon: "Hyperexpression of mitogen-activated protein kinase in human breast cancer." in: The Journal of clinical investigation, Vol. 99, Issue 7, pp. 1478-83, (1997) (PubMed).

  • Target
    ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
    Andere Bezeichnung
    ERK2 (MAPK1 Produkte)
    Synonyme
    ERK-1 antikoerper, ERK1 antikoerper, ERT2 antikoerper, HS44KDAP antikoerper, HUMKER1A antikoerper, P44ERK1 antikoerper, P44MAPK antikoerper, PRKM3 antikoerper, p44-ERK1 antikoerper, p44-MAPK antikoerper, Erk-1 antikoerper, Erk1 antikoerper, Ert2 antikoerper, Esrk1 antikoerper, Mnk1 antikoerper, Mtap2k antikoerper, Prkm3 antikoerper, p44 antikoerper, p44erk1 antikoerper, p44mapk antikoerper, ERK antikoerper, ERK2 antikoerper, ERT1 antikoerper, MAPK2 antikoerper, P42MAPK antikoerper, PRKM1 antikoerper, PRKM2 antikoerper, p38 antikoerper, p40 antikoerper, p41 antikoerper, p41mapk antikoerper, 9030612K14Rik antikoerper, AA407128 antikoerper, AU018647 antikoerper, C78273 antikoerper, Erk2 antikoerper, Prkm1 antikoerper, p42mapk antikoerper, zERK2 antikoerper, MAPK1 antikoerper, Xp42 antikoerper, erk antikoerper, erk2 antikoerper, ert1 antikoerper, mapk antikoerper, mapk1b antikoerper, mapk2 antikoerper, mpk1 antikoerper, prkm1 antikoerper, prkm2 antikoerper, mapk1 antikoerper, mapk1a antikoerper, xp42 antikoerper, ATMPK1 antikoerper, F14N23.9 antikoerper, F14N23_9 antikoerper, MITOGEN-ACTIVATED PROTEIN KINASE antikoerper, mitogen-activated protein kinase 1 antikoerper, MNK1 antikoerper, ATMPK2 antikoerper, MITOGEN-ACTIVATED PROTEIN KINASE HOMOLOG 2 antikoerper, T30E16.13 antikoerper, T30E16_13 antikoerper, mitogen-activated protein kinase homolog 2 antikoerper, mitogen-activated protein kinase 3 antikoerper, mitogen-activated protein kinase 1 antikoerper, mitogen activated protein kinase 1 antikoerper, mitogen-activated protein kinase 1 L homeolog antikoerper, mitogen-activated protein kinase 1 S homeolog antikoerper, mitogen activated protein kinase 3 antikoerper, mitogen-activated protein kinase homolog 2 antikoerper, MAPK3 antikoerper, Mapk3 antikoerper, MAPK1 antikoerper, Mapk1 antikoerper, mapk1 antikoerper, mapk1.L antikoerper, mapk1.S antikoerper, PfMAP1 antikoerper, MPK1 antikoerper, PVX_084965 antikoerper, LOC9328617 antikoerper, Tsp_01601 antikoerper, MPK2 antikoerper
    Hintergrund
    The members of the Mitogen-Activated Protein Kinase (MAPK) family are components of a key signal transduction cascade that links events at the cell surface to responses in the nucleus. The signaling cascade is found in species as varied as yeast and humans, with many of the proteins being well conserved. In mammals the most widely studied members of the cascade are the Extracellular signal-Regulated Kinases, ERK1 (p44 MAPK) and ERK2 (p42 MAPK). ERK1 and ERK2 share 85% homology and are activated by extracellular signals such as growth factors, hormones, and phorbol esters. Activation occurs through a series of phosphorylations by kinases activating other kinases and eventually leading to phosphorylation of the ERKs. Growth factor stimulation leads to activation of Ras and Raf, leading to phosphorylation of MEK1 (MAPK/ERK kinase) which, in turn, activates the ERKs via dual phosphorylation. Once activated, the ERKs phosphorylate other cytoplasmic signalling molecules (protein kinases and phosphatases), cell-surface receptors, microtubule-associated proteins, and transcription factors in the nucleus. Thus, the active ERK has myriad downstream effectors that implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Furthermore, studies have shown that elevated ERK activity is associated with some cancers. The G263-7 recognizes ERK2. It does not cross-react with ERK1. Clone G263-7 was originally characterized in human (A431) and mouse (NIH/3T3) cells.A human ERK2 synthetic peptide was used as immunogen.
    Pathways
    MAPK Signalweg, RTK Signalweg, Apoptose, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagie, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, S100 Proteine
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