ITGA4 Antikörper (Biotin)
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- Target Alle ITGA4 Antikörper anzeigen
- ITGA4 (Integrin alpha 4 (ITGA4))
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Reaktivität
- Human
- Wirt
- Bitte anfragen
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Klonalität
- Monoklonal
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Konjugat
- Dieser ITGA4 Antikörper ist konjugiert mit Biotin
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Produktmerkmale
- The CD49d antigen is primarily expressed on T and B lymphocytes and weakly expressed on monocytes.
- Klon
- ALC1-1
- Isotyp
- IgG1
- Top Product
- Discover our top product ITGA4 Primärantikörper
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- Applikationshinweise
- It is recommended for use in flow cytometry This reagent is effective for direct immunofluorescence staining of human tissue for flow cytometric analysis using 10 µl, 1/100, of the suggested working dilution to label 10^6 cells.
- Kommentare
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BIOTIN(Sigma) Reactivity and.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- The conjugate is provided in liquid form in buffer containing Antibody Stabilizer Solution, PBS and 0,09% Sodium azide, pH 7,4.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- 1. The device is not intended for clinical use including diagnosis, prognosis, and monitoring of a disease state, and it must not be used in conjunction with patient records or treatment. 2. This product contains Sodium azide (NaN3), a chemical highly toxic in pure form. At product concentrations, though not classified as hazardous, Sodium azide may react with lead and copper plumbing to form highly explosive build-ups of metal azides. Upon disposal, flush with large volumes of water to prevent metal azide build-up in plumbing. 3. As with any product derived from biological sources, proper handling procedures should be used.
- Lagerung
- 4 °C
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- Target
- ITGA4 (Integrin alpha 4 (ITGA4))
- Andere Bezeichnung
- CD49d (ITGA4 Produkte)
- Synonyme
- CD49D antikoerper, IA4 antikoerper, LOC100219853 antikoerper, integrin subunit alpha 4 antikoerper, integrin alpha 4 antikoerper, integrin subunit alpha 4 S homeolog antikoerper, ITGA4 antikoerper, Itga4 antikoerper, itga4.S antikoerper
- Hintergrund
- CD49d (Anti-VLA-alpha-4) recognizes the 150-kDa alpha-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of alpha and beta subunits and is involved in cell-cell and cell-extracellular matrix interactions. The beta-chain of the VLA-4 complex is the CD29 antigen, a 130-kDa glycoprotein. The CD29 antigen, also known as the beta-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell- adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B- lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the beta integrin, forms a lymphocyte homing receptor for Peyer's patch, binding to the mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.
- Pathways
- Integrin Complex
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